Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives

Distinct substances, with completely different mechanisms of action, might lead or precipitate the genesis of HPPD, therefore suggesting a multifaceted etiology. Thus, it is accordingly conceivable that different medications could be useful and helpful in the treatment of different subtypes of HPPD. Tracers and trailing phenomena appear to be the most resistant symptoms.

hppd disorder

Study Selection

hppd disorder

Case 10 had significantly reduced color perception with 5/17 OS (oculus sinister, left eye) and 4/17 OD (oculus dexter, right eye). Mood swings, reported by 35% of individuals with HPPD, involve sudden shifts in emotional states, ranging from euphoria to sadness or irritability. Mood swings may be linked to altered neurotransmitter activity, particularly involving serotonin and dopamine, which are essential for mood stabilization. Avoiding drug use, seeking therapy, staying connected to support systems, and practicing stress-reducing techniques can help manage HPPD symptoms.

  • The clinical and lay literature around HPPD has evolved in parallel to consider condition one of ‘drugs’ in the abstract, which is still separate from VSS and others.
  • In this blog, we’ll explore what HPPD is, its symptoms, causes, and treatment options, providing valuable insights for those affected and their loved ones.
  • People with Hallucinogen Persisting Perception Disorder re-experience the same hallucinations they had on a past psychedelic “trip.” Oftentimes, these hallucinations are visual but they can affect the other senses as well.

Hallucinogen persisting perception disorder

Anti-seizure and epilepsy medicines like Klonopin (clonazepam) and Lamictal (lamotrigine) have been used in the treatment of HPPD, however, there is no recognized medical treatment for flashbacks. Occasionally, people or situations may seem bizarre or ridiculous, or the person experiencing the flashback may feel dissociated. When this happens in a social situation requiring self-control, it can be embarrassing or scary for the person experiencing it. As chief Clinical Officer at FHE Health, a nationally recognized behavioral health treatment provider, he ensures quality, innovation, and comprehensive treatment for patients. Learning relaxation techniques like deep breathing or mindfulness exercises can help those with HPPD disorder remain more in control when flashbacks occur. Taking steps to manage stress through exercise, enjoying hobbies, socializing with others, listening to music and engaging in other activities may help reduce the frequency of flare-ups.

Symptoms and Signs of HPPD

HPPD (Hallucinogen Persisting Perception Disorder) is an under-researched neuro-psychological condition involving distressing changes to visual perception following the use of drugs, including and especially psychedelic drugs. The Perception Restoration Foundation promotes and funds research, support and awareness-raising around HPPD. Although researchers don’t know why some people get HPPD and others don’t, they know HPPD happens because you’ve used hallucinogenic drugs in the past. According to studies, the amount of a substance you took doesn’t seem to make a difference in your risk of getting HPPD. According to a 2003 study, HPPD is reported most commonly after illicit use of LSD. There are also reports of people who have only used hallucinogens once or twice experiencing similar symptoms.

hppd disorder

  • Treatment may not lead to complete recovery, and patients, especially those with Type II, must learn to cope with the visual disturbances.
  • While these findings are encouraging, they stem from a single case study.
  • It’s almost as if life itself is inviting us to embrace difficulty—not as punishment but as a design feature.
  • If any issues arise, participants are advised to contact me at u @uel.ac.uk.

A further important finding is that schizophrenia patients with comorbid HPPD have higher rates of having a “bad trip” than those without HPPD. This may suggest a link between specific immediate LSD effects and the chance of developing other pervasive LSD-related diseases. Furthermore, individuals who have schizophrenia and HPPD may not have HPPD-related perceptual symptom improvement 10. The patient developed and reported several hallucinogen-induced perceptual symptoms for the first time after seven months of complete cessation of LSD. His symptoms affected enough of his social, professional, and other areas of functioning to be admitted to the hospital. However, Criteria C of the DSM-5 could not be met due to the patient’s history of schizophrenia.

It was first included as a diagnosis in the Diagnostic and Statistical Manual of Mental Disorders, or DSM, more than 30 years ago — yet many psychiatrists and other clinicians still have no idea the disorder exists. If you are concerned about your frequent hallucinogen use or are experiencing the symptoms of HPPD, help is available. Contact a treatment provider today to learn more about your treatment options. Tolerance occurs when someone uses the same dose of drug addiction treatment a drug regularly, and over time, the drug’s effects decrease.

Dr. Wesley Ryan, who has treated about a dozen people with HPPD at his psychiatric practice in Marina del Rey, said such patients often experience depersonalization and derealization. They feel like they are witnessing their own life from the outside or that nothing is real. Some with the condition live for years with frequent or near-constant visual aberrations. Many develop serious psychological and mental conditions, including anxiety, depression and dissociation from reality. The exact cause of HPPD is not fully understood, and researchers continue to search for a definitive answer. Some reports state flashbacks occur due to how a person’s nervous system reacts to using hallucinogens.

He used to enjoy books but hasn’t been able to read anything longer than a few hppd disorder pages since the symptoms began. He often uses voice to text on his phone because his perception of words and letters is so scrambled. Start your recovery journey with peace of mind, knowing your care is covered. If a history of psychedelic drug use is known, HPPD may be diagnosed correctly.

  • HPPD is related to the recreation of symptoms experienced in intoxication.
  • Therefore, recognizing and addressing these symptoms may significantly improve the quality of life for those affected by this disorder.
  • His symptoms affected enough of his social, professional, and other areas of functioning to be admitted to the hospital.
  • Hallucinogen-persisting perception disorder causes many symptoms, predominantly persistent visual perception distortion instead of intermittent distortion.
  • Though there is no treatment available for Hallucinogen Persisting Perception Disorder, DSM-5 has characterized certain restriction criteria to rule out specific conditions – for better diagnosis of this disorder.

However, HPPD I usually onsets with warning “auras”, minor feelings of self-detachment, mild bewilderment, and mild depersonalization and derealization 17,18. Conversely, the onset of HPPD II might be unexpected and abruptly detonate with bursting “auras”, deep feelings of self-detachment, acute depersonalization-derealization 19. HPPDs are poorly understood due to the enormous range and variability of recurrent sensory disturbances, and the multiple distinct subtypes 17,18.

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